Preadipocyte uncoupling protein 1 expression invoked by fibroblast growth factors imprints on post-differentiation white and brown adipocyte function
Katharina Kuellmer, C Moench, Wilma Roch, Christine Wurmser, Brice Emanuelli, Patricia S. S. Petersen, Hildigunnur Hermannsdóttir, Mersiha Hasić, Tobias Fromme
This study shows that fibroblast growth factors induce Ucp1 in preadipocytes, which suppresses interferon-stimulated genes after differentiation, programming post-differentiation inflammatory status.
bioRxiv · Jun 26, 2025 · PreprintMolecular Biology