Melatonin Partially Attenuates Oxycodone-Induced Placental Stress Signaling and Fetal Brain Apoptosis in a Sex-Specific Manner.
Isaac Oluwole Adediji, Kajal Kamra, Hager M. Kowash, Pegah Nouri Mousa, Christianah Oreoluwa Aloba, Victoria L. Schaal, John S. Davis, Eric S. Peeples, Gurudutt Pendyala, Lynda K. Harris
This study examines how prenatal oxycodone exposure affects placental and fetal brain stress signaling and apoptosis, and whether melatonin can mitigate these effects in a sex-specific manner.
bioRxiv · May 1, 2026 · PreprintDevelopmental Biology