Downregulated expression of hepatic β-Klotho is associated with the hypertensive phenotype in SHR
Pedro Sousa Soares, Giovanna Nunes de Oliveira, Paula Magalhães Gomes, Vagner Roberto Antunes
This study finds that hepatic β-Klotho is downregulated in hypertensive SHR, suggesting peripheral FGF-21 resistance links metabolic dysfunction to hypertension.
bioRxiv · Oct 27, 2025 · PreprintPhysiology