Author

Charles R.G. Guttmann

Brigham and Women's HospitalORCID 0000-0002-7006-9762Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1

Frequent Co-Authors

Abel G. Silva-Filho· 1 shared Alfredo PinzóniD· 1 shared Amirreza MahbodiD· 1 shared Anne KerbratiD· 1 shared April KhademiiD· 1 shared Athanasios Ploumakis· 1 shared Audrey Istace· 1 shared Baptiste LaurentiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Abel G. Silva-Filho

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2 papers

Recent·Most cited

Sex differences in progressive multiple sclerosis brain gene expression in oligodendrocytes and OPCs

Brenna A. LaBarre, Devin A. King, Athanasios Ploumakis, Alfredo Pinzón, Charles R.G. Guttmann, Nikolaos A. Patsopoulos, Tanuja Chitnis

The paper analyzes gene expression differences in oligodendrocytes and OPCs from female and male progressive MS patients, identifying sex-specific up-regulated genes and mitochondrial pathways associated with neurodegenerative diseases.

BMC Medical Genomics · Dec 12, 2025Peer-reviewedNeuroscience

Objective Evaluation of Multiple Sclerosis Lesion Segmentation using a Data Management and Processing Infrastructure

Olivier Commowick, Audrey Istace, Michaël Kain, Baptiste Laurent, Florent Leray, Mathieu Simon, Sorina Camarasu-Pop, Pascal Girard, Roxana Améli, Jean‐Christophe Ferré, Anne Kerbrat, Thomas Tourdias, Frédéric Cervenansky, Tristan Glatard, Jérémy Beaumont, , Christian Barillot

This paper evaluates MS lesion segmentation algorithms using a new open-science infrastructure, finding that automatic methods lag behind human experts in detection and delineation.

Scientific Reports · Sep 6, 2018Peer-reviewedNeuroscience