Does a map-level insulation constraint improve sequence-based prediction of 3D genome folding? A Stage 1 Registered Report with a reverse-complement-equivariant state-space model (HiFold-Mamba)
Mohammad Malekpouri, Somayeh Lotfi
The paper evaluates whether insulation-based losses improve sequence-based prediction of 3D genome folding using a reverse-complement-equivariant state-space model, finding improvements in boundary and loop prediction.
bioRxiv · Oct 30, 2026 · PreprintBioinformatics