Author

Spencer C Ding

Stanford MedicineORCID 0000-0002-7244-5995Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Research Focus:differential expression· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Jingru YuiD· 2 shared Tiepeng LiaoiD· 2 shared Wei GuiD· 2 shared Benjamin A. PinskyiD· 1 shared Chandler C. HoiD· 1 shared Chinmay Rao· 1 shared Cindy YangiD· 1 shared Lauren S. AhmanniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenomics

Jingru YuORCID

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2 papers

Recent·Most cited

Early Prenatal Cell-Free DNA Methylation Landscape Informs Epigenetic Purification of the Circulating Fetal Genome

Tiepeng Liao, Chinmay Rao, Siya Iyer, Spencer C Ding, Jingru Yu, Zackary Lui, Cindy Yang, Wei Gu

The paper develops an epigenetic enrichment method for fetal cfDNA using a first-trimester methylome reference, increasing fetal fraction from 5.1% to 28.4%.

bioRxiv · Oct 25, 2026 · PreprintGenomics

Adapting Clinical Chemistry Plasma as a Source for Liquid Biopsies

Spencer C Ding, Jingru Yu, Tiepeng Liao, Lauren S. Ahmann, Yvette Y. Yao, Chandler C. Ho, Linlin Wang, Benjamin A. Pinsky, Wei Gu

The paper evaluates using residual plasma from heparin separators for cfDNA testing, showing high concordance with EDTA and Streck samples for methylation, fragmentation, and viral detection.

eLife · May 1, 2026Peer-reviewedGenetic & Genomic Medicine