Fine-tuning of conditional Transformers for the generation of functionally characterized enzymes
M. Nicolini, Emanuele Saitto, Ruben Emilio Jimenez Franco, Emanuele Cavalleri, Marco Mesiti, Aldo Galeano, Dario Malchiodi, Alberto Paccanaro, Peter N. Robinson, Elena Casiraghi, Giorgio Valentini
This paper introduces Finenzyme, a Protein Language Model that improves EC category prediction through fine-tuning, generating functionally similar enzymes with preserved structure and function.
bioRxiv · Aug 10, 2024 · PreprintBioinformatics