Nuclear TSC2 drives miR-514b-3p transcription to regulate PI3K-AKT-MTOR signalling: Implications for OSCC pathogenesis
Sakshi Gupta, Naresh Mahajan, M Krishna Kumar, Arun Kumar
This study identifies TSC2 as a transcriptional repressor of miR-514b-3p, which regulates the PI3K-AKT-MTOR pathway through TSPAN9, revealing a novel nuclear function of TSC2 in OSCC pathogenesis.
bioRxiv · Apr 19, 2026 · PreprintCancer Biology