Author

Henne H. Holstege

Amsterdam NeuroscienceORCID 0000-0002-7688-3087Unclaimed ORCID profile · follow to get notified of new preprints

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25 shared papersGenetic & Genomic Medicine

Marc HulsmanORCID

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32 papers

Recent·Most cited

GeneticsEuropean Journal of Human GeneticsPeer-reviewedSep 26, 2018

Centenarian Controls Increase Variant Effect-sizes by an average two-fold in an Extreme Case-Extreme Control Analysis of Alzheimer’s Disease

Niccoló Tesi, Sven J. van der Lee, Marc Hulsman…·Henne H. Holstege

This study shows that using centenarians as extreme controls increases AD variant effect-sizes by two-fold, enabling replication in small samples.

65 citationstop 4%

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NeuroscienceActa Neuropathologica CommunicationsPeer-reviewedJul 23, 2018

Neuropathology and cognitive performance in centenarians

Andrea B. Ganz, Nina Beker, Marc Hulsman…·Henne H. Holstege

This study examines neuropathological hallmarks in centenarians' brains and their association with cognitive performance, finding that some pathologies correlate with lower cognitive test results.

66 citationstop 3%

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