Mutational signatures in upper tract urothelial carcinoma define etiologically distinct subtypes with prognostic relevance
Xuesong Li, Huan Lü, Bao Guan, Zhengzheng Xu, Yue Xi Shi, Juan Li, Wenwen Kong, Jin Liu, Dong Fang, Libo Liu, Qi Shen, Yanqing Gong, Shiming He, Qun He, Liqun Zhou, Weimin Ci
The paper identifies three mutational subtypes in UTUC linked to AA exposure, aging, and DNA repair, with distinct clinical outcomes and therapeutic implications.
bioRxiv · Aug 15, 2019 · PreprintGenomics