Single-cell genetics identifies cell-type-specific effector genes across complex traits and diseases
Albert Henry, Anne Senabouth, Mubarika Tyebally, Blake Bowen, Peter C. Allen, Eleanor Spenceley, Eszter Sagi-Zsigmond, Rachael A McCloy, Anna S. E. Cuomo, Jianan Fan, Hao Lawrence Huang, Hope A. Tanudisastro, Angli Xue, Oscar Dong, Bradley T Harris, , Joseph E. Powell
The paper uses single-cell eQTL data to identify cell-type-specific effector genes associated with 69 diseases and 31 biomarker traits, revealing distinct immune cell contributions to disease.
medRxiv · Aug 28, 2025 · PreprintGenetic & Genomic Medicine