BioinformaticsbioRxivPreprint
Optimizing Polygenic Scores for Complex Morphological Traits: A Case Study in Nasal Shape Prediction
Meng Yuan, Seppe Goovaerts, Nina Claessens…·Peter D. Claes
This paper improves polygenic prediction of nasal shape by using multivariate GWAS, optimized phenotypes, and benchmarked PGS methods, achieving higher variance explained than traditional approaches.
DOI 10.1101/2025.09.14.676081