Distinguishing excess mutations and increased cell death based on variant allele frequencies
Gergely Tibély, Dominik Schrempf, Imre Derényi, Gergely J. Szöllősi
The paper develops a method to estimate cell turnover and mutation rates from bulk sequencing data, finding both are elevated in a hepatocellular carcinoma sample.
bioRxiv · Feb 12, 2021 · PreprintBioinformatics