Author

Thomas L. Casavant

University of IowaORCID 0000-0002-8051-4153Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:variant effect prediction· 2 Approach:Bayesian inference· 1 Assay:DNA methylation· 1 Approach:machine learning (classical)· 1 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Terry A. BrauniD· 2 shared Arthur Duston OdelliD· 1 shared Benjamin W. DarbroiD· 1 shared Brian Hong· 1 shared Brian J SmithiD· 1 shared Chloe Ovel· 1 shared Diana L. KolbeiD· 1 shared Elizabeth S. PhillippiiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenetics

Terry A. BraunORCID

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2 papers

Recent·Most cited

The prevalence of protein misfolding as a mechanism for hereditary deafness

Rose A. Gogal, Genevieve M. Cox, Diana L. Kolbe, Arthur Duston Odell, Chloe Ovel, Katherine McCormick, Brian Hong, Héla Azaiez, Thomas L. Casavant, Richard J. Smith, Terry A. Braun, Michael J. Schnieders

The paper evaluates computational frameworks to prioritize pathogenic variants in deafness-associated genes, identifying 28,866 VUSs with high pathogenicity probability and improving diagnoses for 12 patients.

PLoS Genetics · Sep 30, 2026Peer-reviewedGenetics

Genome-wide Machine Learning Analysis of Anosmia and Ageusia with COVID-19

Lucas Pietan, Elizabeth S. Phillippi, Marcelo Melo, Hatem El‐Shanti, Brian J Smith, Benjamin W. Darbro, Terry A. Braun, Thomas L. Casavant

The paper uses genome sequencing data and machine learning to identify genetic factors associated with anosmia and ageusia in COVID-19 patients.

PLoS ONE · Aug 13, 2026Peer-reviewedGenetic & Genomic Medicine