Secondary structure distances reveal a new dimension of protein evolution
Adolfo Bastida, Ana Maria Muñ oz Morales, Marcos Egea‐Cortines
This paper introduces a secondary structure distance metric to analyze protein evolution, showing structural divergence can differ from sequence-based phylogeny, especially in proteins with ordered and disordered regions.
bioRxiv · May 1, 2026 · PreprintEvolutionary Biology