Nephrotoxicity of Immune Checkpoint Inhibitors in Mice with a Human Immune System
Sarah C. Asby, Xia Wen, Michael J. Goedken, Brianna Ames, Shams Gamal Eldin Shams, Lauren E. Thompson, Jordi M. Lanis, Zander C. Kostka-Newman, Kristina Larsen, Scott G. Tilden, Julie Lang, Lauren M. Aleksunes, Melanie S. Joy
This study investigates ICI-related kidney injury in a humanized mouse model, identifying immune biomarkers and mechanisms of nephrotoxicity.
bioRxiv · May 12, 2026 · PreprintPharmacology & Toxicology