Database size positively correlates with the loss of species-level taxonomic resolution for the 16S rRNA and other prokaryotic marker genes
Seth Commichaux, Tu Luan, Harihara Subrahmaniam Muralidharan, Mihai Pop
The paper shows that larger reference databases reduce species-level taxonomic resolution for prokaryotic marker genes, suggesting the need for more precise definitions and combined markers for accurate classification.
PLoS Computational Biology · Aug 5, 2024Peer-reviewedBioinformatics