Disentangled generative modeling of single-cell perturbation responses across dynamic cellular states
Yue Wang, Yueshan Zhao, Sihan Li, Da Yang
This paper introduces PertVI, a deep generative model that disentangles treatment effects from cellular state and batch effects in single-cell perturbation data, revealing state-specific transcriptional responses.
bioRxiv · Nov 10, 2026 · PreprintBioinformatics