Mechanistic basis for GPCR phosphorylation-dependent allosteric signaling specificity of β-arrestin 1 and 2
Midhun K. Madhu, Rajesh K. Murarka
This study maps how phosphorylation patterns shape β-arrestin structure and function using simulations and machine learning, revealing isoform-specific allosteric responses and effector engagement.
bioRxiv · Apr 29, 2025 · PreprintBiophysics