Ji‐Yong Sung

Structure constrained spin responses of an FMN superoxide radical-pair model in mitochondrial complex I

The paper examines how the geometry of the FMN pocket in mitochondrial complex I influences spin responses and singlet yields under varying conditions.

Kinetic gating by an iron sulfur chain modulates flavin radical-pair spin chemistry in mitochondrial Complex I

The paper models spin chemistry in mitochondrial Complex I's flavin radical pair, showing kinetic gating by iron sulfur clusters affects singlet yield and spin coherence.

Cancers relax selection on charge at the mitochondrial complex I quinone cavity

The paper analyzes charge and connectivity constraints in mitochondrial complex I proton wires, finding that tumors selectively enrich charge-related mutations at specific sites.

Relaxed evolutionary constraints on mitochondrial electron-transfer-associated variants in human cancers

The paper predicts how MT-CYB mutations affect electron transfer in cancer and finds they are depleted in germline but enriched in tumors.

Delocalized DNA holes imprint mutation position in mismatch-repair-deficient cancers

The paper identifies a specific mutation pattern in mismatch-repair-deficient cancers linked to DNA hole delocalization and oxidation, showing enrichment at 5' guanines and depletion at 3' guanines.

A Spin-Glass Metabolic Hamiltonian optimized by Quantum Annealing Reveals Configurational Regimes of Cancer Metabolism

This paper introduces a spin-glass metabolic model to analyze cancer metabolism, finding that gene expression reshapes metabolic landscapes and identifies a prognostic order parameter.

Geometry derived Hamiltonian organization distinguishes recurrent biological Fe S architectures

The paper analyzes Fe-S clusters to show geometry-derived Hamiltonian organization links structural features with transport behavior and taxonomic recurrence.

Gene Program Negotiation Defines Cellular Identity in Single-Cell Transcriptomes

This paper introduces Gene Program Negotiation (GPN), a framework to analyze regulatory interactions in single-cell transcriptomes, revealing new regulatory states and their association with cellular plasticity.

FateLimit quantifies the prediction horizon of cell fate

FateLimit quantifies when future cell identities become predictable from current molecular states across multiple developmental systems.

Protein-glass microenvironments define electron transfer vulnerability in Leigh syndrome

This paper identifies protein-glass microenvironments in Complex I that correlate with electron transfer vulnerability in Leigh syndrome mutations.

Information Geometry of Intracellular Compartment Coupling Reveals Transcriptomic State Transitions in Single Cells

The paper introduces CCE, a framework to analyze transcriptomic coupling between intracellular compartments, revealing state transitions in single cells through information-geometric metrics.

Quantum transport in mitochondrial complex I is governed by a conserved structural bottleneck

The paper uses quantum walk analysis to show that a conserved structural bottleneck in mitochondrial complex I redistributes electron flux through alternative pathways across species.