Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction
Yixuan He, Wenhan Lu, Yon Ho Jee, Mu-Yi Shih, Ying Wang, Kristin Tsuo, David C. Qian, James A. Diao, Hailiang Huang, Chirag J. Patel, Jinyoung Byun, Bogdan Paşaniuc, Elizabeth G. Atkinson, Christopher Ian Amos, Yen‐Chen Anne Feng, , Alicia R. Martin
This paper improves genetic discovery and polygenic risk prediction for respiratory diseases by analyzing multiple traits and ancestries, identifying novel loci and developing a new polygenic risk score method.
Nature Genetics · Jan 21, 2026Peer-reviewedGenetic & Genomic Medicine