Author

David S.M. Lee

University of PennsylvaniaORCID 0000-0002-8821-9028Unclaimed ORCID profile · follow to get notified of new preprints

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David S.M. Lee1 paper

Biology Disciplines

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Louis R. GhanemiD· 2 shared Yoseph BarashiD· 2 shared Andrew Kromer· 1 shared Aris BarasiD· 1 shared Daniel James RaderiD· 1 shared Joseph ParkiD· 1 shared Marylyn DeRiggi RitchieiD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersGenomics

Louis R. GhanemORCID

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2 papers

Recent·Most cited

GenomicsNature CommunicationsPeer-reviewedMar 9, 2021

Disrupting upstream translation in mRNAs leads to loss-of function associated with human disease

David S.M. Lee, Joseph Park, Andrew Kromer…·Yoseph Barash

The paper identifies uORF variants that disrupt upstream translation and are under strong negative selection, linking them to gene-disease associations and loss-of-function in human genes.

65 citations

humanwhole-exome sequencing

GenomicsNature CommunicationsPeer-reviewedJan 27, 2020

Integrative analysis reveals RNA G-Quadruplexes in UTRs are selectively constrained and enriched for functional associations

David S.M. Lee, Louis R. Ghanem, Yoseph Barash

The paper identifies G-quadruplex sequences in UTRs as functionally constrained and enriched for cis-eQTLs and RNA-binding protein interactions, linking them to disease associations.

97 citationstop 3%

humanbulk RNA-seq