Andrew V. Grassetti

Heterogeneous reconstruction algorithms for cryoEM achieve limited particle classification accuracy on real benchmark datasets

This study evaluates heterogeneous reconstruction algorithms in cryoEM using benchmark datasets with ground-truth labels, finding limited accuracy in particle classification despite resolving structural heterogeneity.

Engineered Cas9 complexes establish an experimentally grounded benchmark for heterogeneous cryoEM reconstruction methods

The paper develops an experimentally grounded benchmark dataset for heterogeneous cryoEM reconstruction using engineered Cas9 complexes with defined DNA extensions.