Use of amplicon-based sequencing for testing fetal identity and monogenic traits with single circulating trophoblast (SCT) prenatal diagnosis
Xinming Zhuo, Qun Wang, Liesbeth Vossaert, Roseen Salman, Adriel Kim, Ignatia B. Van den Veyver, Amy M. Breman, Arthur L. Beaudet
This paper describes a method using amplicon-based sequencing to identify fetal cells and detect monogenic mutations in single circulating trophoblast cells for non-invasive prenatal testing.
PLoS ONE · Apr 15, 2021Peer-reviewedGenetic & Genomic Medicine