Primitive purine biosynthesis connects ancient geochemistry to modern metabolism
Joshua E. Goldford, Harrison B. Smith, Liam M. Longo, Boswell A. Wing, Shawn E. McGlynn
The paper models ancient metabolic networks to show purine synthesis was a bottleneck in metabolic evolution, requiring non-autocatalytic phosphoryl agents and leading to coenzyme emergence.
Nature Ecology & Evolution · Mar 22, 2024Peer-reviewedSystems Biology