Author

Leonard C. Edelstein

Thomas Jefferson UniversityORCID 0000-0002-8976-6410Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:Bayesian inference· 1 Research Focus:differential expression· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Andrew R. GhaziiD· 2 shared Chad A. ShawiD· 2 shared Edward S. CheniD· 2 shared Xianguo Kong· 2 shared Namrata Madan· 1 shared

Activity by Year

2019-2020 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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2 shared papersBioinformatics

Andrew R. GhaziORCID

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2 papers

Recent·Most cited

Bayesian modelling of high-throughput sequencing assays with malacoda

Andrew R. Ghazi, Xianguo Kong, Ed Chen, Leonard C. Edelstein, Chad A. Shaw

The paper develops a Bayesian framework for analyzing NGS functionalization screens and introduces the malacoda R package to improve variant function analysis.

PLoS Computational Biology · Jul 21, 2020Peer-reviewedBioinformatics

Identification of functional variants for platelet CD36 expression by Massively Parallel Reporter Assay.

Namrata Madan, Andrew R. Ghazi, Xianguo Kong, Edward S. Chen, Chad A. Shaw, Leonard C. Edelstein

The paper identifies functional variants regulating CD36 expression using MPRA and confirms their impact on platelet function and cardiovascular disease risk.

PLoS Genetics · Jul 25, 2019Peer-reviewedGenomics