Deep Neural Networks Predict MHC-I Epitope Presentation and Transfer Learn Neoepitope Immunogenicity
Benjamin Alexander Albert, Yunxiao Yang, Xiaoshan M. Shao, Dipika Singh, Kellie Nicole Smith, Valsamo Anagnostou, Rachel Karchin
The paper introduces BigMHC, a deep learning model that predicts MHC-I epitopes and immunogenic neoepitopes with high accuracy, outperforming existing methods.
Nature Machine Intelligence · Jul 20, 2023Peer-reviewedBioinformatics