Early-Life Immune Activation Shapes Microglial Responses and Reduces Abeta Pathology in 5xFAD mice
Yiyi Yang, Marta García-Cruzado, Hairuo Zeng, Xinrui Wang, Sara Bachiller, Lluís Camprubí-Ferrer, Bazhena Bahatyrevich-Kharitonik, Rosalía Fernández‐Calle, Tomas Deierborg
This study shows that early-life immune activation in 5xFAD mice alters microglial responses and reduces Aβ pathology, with effects on cytokine levels and memory deficits.
bioRxiv · Nov 19, 2024 · PreprintNeuroscience