Author

James L. Cole

University of ConnecticutORCID 0000-0002-9028-8364Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Aaron G. Feinstein· 1 shared Eric R. MayiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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2 top collaborators · 1 mutual co-author link

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1 shared paperBiophysics

Aaron G. Feinstein

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1 paper

Recent·Most cited

The αC helix is a central regulator of PKR activation

Aaron G. Feinstein, James L. Cole, Eric R. May

This study investigates the structural mechanism of PKR activation, showing that back-to-back dimerization stabilizes a catalytically competent conformation through the C helix.

The Journal of Physical Chemistry B · Sep 18, 2024Peer-reviewedBiophysics