Fibrotic Extracellular Matrix Preferentially Induces a Partial Epithelial-Mesenchymal Transition Phenotype in a 3-D Agent Based Model of Fibrosis
Kristin P. Kim, Christopher A. Lemmon
This paper develops a 3-D agent-based model of fibrosis to show that fibrotic ECM promotes a partial EMT state through TGF-β1-FN tethering, independent of TGF-β1 concentration.
Mathematical Biosciences · Jan 1, 2024Peer-reviewedCell Biology