Medroxyprogesterone acetate mediated alteration in the vaginal microbiota and microenvironment in a Kenyan sex worker cohort
Jocelyn M. Wessels, Julie Lajoie, Maeve I. J. Hay Cooper, Kenneth Omollo, Allison Marjorie Felker, Danielle Vitali, Haley A. Dupont, Philip V. Nguyen, Kristen Mueller, Fatemeh Vahedi, Joshua Kimani, Julius Otieno Oyugi, Juliana Cheruiyot, John N. Mungai, Alexandre Deshière, , Charu Kaushic
This study shows that Medroxyprogesterone Acetate (MPA) increases vaginal microbiota diversity and reduces glycogen and amylase, which correlates with increased HIV-1 susceptibility in Kenyan sex workers and humanized mice.
Disease Models & Mechanisms · Sep 19, 2019Peer-reviewedMolecular Biology