Type 1-polarized DC immunotherapeutic contains heterogeneous populations with IL-12p70 production restricted to a rare subset
Allison E. DePuyt, Peter E. J. Shoucair, Holly A. Bilben, Jeremy James Martinson, Bernard J. C. Macatangay, Charles R. Rinaldo, Paweł Kaliński, Robbie B. Mailliard
The paper identifies heterogeneous subpopulations within Type 1-polarized dendritic cells (DC1) and shows that IL-12p70 production is restricted to a rare subset, with implications for clinical variability.
bioRxiv · May 2, 2026 · PreprintImmunology