Tumor Copy Number Deconvolution Integrating Bulk and Single-Cell Sequencing Data
Haoyun Lei, Bochuan Lyu, Edward Michael Gertz, Alejandro A. Schäffer, Xulian Shi, Kui Wu, Guibo Li, Liqin Xu, Yong Hou, Michael C. Dean, Russell S. Schwartz
The paper develops methods to deconvolve tumor copy number data by integrating bulk and single-cell sequencing data, improving accuracy over bulk data alone.
Journal of Computational Biology · Mar 17, 2020Peer-reviewedBioinformatics