Control of the force-bearing properties of microtubule-associated proteins via stalk/linker regions: insights from the NDC80 complex
I. B. Kovalenko, Холина Екатерина Георгиевна, Vladimir Andreevich Fedorov, Egor M. Pozdnyakov, Philipp S. Orekhov, Никита Борисович Гудимчук
This study uses simulations to show how directional mechanical forces affect the unbinding of the NDC80 complex and other MAPs from microtubules, revealing design principles for load-dependent behavior.
bioRxiv · Feb 12, 2025 · PreprintBiophysics