Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: applied to GENFI study
Claire Cury, Stanley Durrleman, David M. Cash…·on behalf of the Genetic FTD Initiative, GENFI
The paper detects pre-symptomatic shape changes in the thalamus using spatiotemporal analysis of MRI scans from the GENFI study, finding differences five years before symptoms appear.