REST/NRSF phosphorylation by CaMKIV regulates its transcriptional repressor activity and half-life
Hanako Tsushima, Beatrice Corradi, Dimitri Shmal, Martina Chiacchiaretta, Nara Liessi, Andrea Di Fonzo, Emanuele Carminati, Andrea Armirotti, Anna Fassio, Luca Matagliano, Anna Rocchi, Fabio Benfenati
This study shows that CaMKIV phosphorylation of REST at Ser-322 reduces its repressor activity and promotes its degradation.
bioRxiv · Sep 4, 2025 · PreprintNeuroscience