Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core
Haidara Nadwa, Z. Faidon Brotzakis, Annalisa Santucci, Daniela Braconi, Michele Vendruscolo
This study identifies helix III destabilization as the initial trigger for SAA1-76 misfolding by exposing its amyloidogenic core through computational simulations.
The Journal of Physical Chemistry Letters · Dec 15, 2025Peer-reviewedBiochemistry