John Connolly

This study shows that systemic iron sequestration via hepcidin reduces CD8+ T cells in pancreas cancer, linking iron dysregulation to tumoral immunity.

The paper develops MAESTRO, a self-supervised deep learning framework to transform immune profiles into embeddings capturing immune health, enabling clinical prediction and precision immunotherapy.

This study analyzes multi-omic data from gliomas to identify therapeutic escape mechanisms and TME evolution, finding that N-glycosylation classifies tumor grade and immune transcriptome predicts GBM survival.