Systemic iron sequestration restricts the intratumoral CD8+ T cell landscape in pancreas cancer
Joshua Schoenfeld, Jahi Noel, Christopher S. McGinnis, Chenlian Fu, Brinda Alagesan, Eduardo Hernandez, Justin Jee, Nikolaus Schultz, Quaid Morris, Scott W. Lowe, Suzanne M. Cloonan, John Connolly, Ronan Chaligne, David Kelsen, Kenneth Yu, , Santosha Adipudi Vardhana
This study shows that systemic iron sequestration via hepcidin reduces CD8+ T cells in pancreas cancer, linking iron dysregulation to tumoral immunity.
bioRxiv · Sep 25, 2026 · PreprintImmunology