CoLa-VAE: A Cell-Cell Communication-Aware Variational Autoencoder for Representation Learning and Expression Denoising
Yeqing Chen, Cong Qi, Hanzhang Fang, Feiyang Luan, Zhirong Zhang, Shivvrat Arya, Zhi Wei
CoLa-VAE improves denoising and representation learning in single-cell data by integrating cell-cell communication information, enhancing downstream analyses like differential communication detection and spatial deconvolution.
bioRxiv · Jun 26, 2026 · PreprintBioinformatics