Sex-specific vulnerability to behavioural and morphological alterations in a mouse model of Parkinson's disease overexpressing mutant A53T alpha-synuclein
Maider Zubelzu, Raphaëlle Bidgood, Ane Murueta‐Goyena, José Ángel Ruíz-Ortega, José Vicente Lafuente, Teresa Morera‐Herreras
This study shows male mice overexpressing mutant A53T alpha-synuclein exhibit earlier and more severe motor deficits and axonal degeneration compared to females in a Parkinson's disease model.
bioRxiv · Jul 30, 2025 · PreprintNeuroscience