Spermiogenesis alterations in the absence of CTCF revealed by single cell RNA sequencing
Ulises Torres-Flores, Fernanda Díaz-Espinosa, Tayde López-Santaella, Rosa Rebollar‐Vega, Aarón Vázquez-Jiménez, Ian Taylor, Rosario Ortiz-Hernández, Olga M. Echeverría, Gerardo H. Vázquez‐Nin, María Concepción Gutiérrez‐Ruíz, Inti Alberto De La Rosa-Velázquez, Osbaldo Reséndis-Antonio, Abrahan Hernández‐Hernández
This study uses single-cell RNA sequencing to show that CTCF depletion causes transcriptional defects during spermiogenesis, leading to sperm abnormalities and infertility.
Frontiers in Cell and Developmental Biology · Mar 30, 2023Peer-reviewedMolecular Biology