Distilling structural representations into protein sequence models
Jeffrey Ouyang-Zhang, Chengyue Gong, Yue Zhao, Philipp Krähenbühl, Adam R. Klivans, Daniel J. Diaz
The paper introduces ISM, a sequence-only model that improves upon ESM2 by incorporating structural information, achieving better performance on mutation stability and structure prediction tasks.
bioRxiv · Nov 8, 2024 · PreprintBioinformatics