The paper develops a computational model to explore how inflammation, serotonin levels, and brain activity interact, and how anti-inflammatory and antidepressant treatments affect depressive symptoms.

Frontiers in Immunology · Apr 25, 2025Peer-reviewedNeuroscience

Dopamine and serotonin interplay for valence-based spatial learning

Carlos Wert-Carvajal, Melissa Reneaux, Tatjana Tchumatchenko, Claudia Clopath A

This study examines how dopamine and serotonin interact to influence spatial learning and cognitive flexibility using a reward-modulated spike time-dependent plasticity model.

Cell Reports · Apr 1, 2022Peer-reviewedNeuroscience

Understanding the role of alterations in cortical D1 receptor sensitivity in shaping working memory maintenance through mesocortical dynamics

Melissa Reneaux, Rahul Gupta

This study uses a neural mass model to show that increased D1 receptor sensitivity narrows and shifts the optimal dopamine range for working memory maintenance and reduces robustness against noise.

PLoS ONE · May 29, 2018Peer-reviewedNeuroscience