Charge-Driven Fibril Recognition and Covalent Disruption of Aβ42 byPaddlewheel Diruthenium Complexes
Alejandro Feito, Andrés R. Tejedor, Alberto Ocaña, Aarón Terán, Antonello Merlino, Daniela Marasco, Santiago Herrero, Jorge R. Espinosa
This study uses atomistic simulations to show how charge changes in diruthenium complexes affect their interaction with Aβ42 fibrils, enhancing fibril disruption through electrostatic tuning.
bioRxiv · Jul 1, 2026 · PreprintBiophysics