Single-cell characterization and machine learning-based classification reveal the transcriptional identity and antigen-experienced features of peripheral CD4+CD8+ double-positive T cells
Eunji Shin, Seung Gyu Yun, Yunjung Cho
The paper identifies and classifies rare peripheral CD4+CD8+ double-positive T cells using single-cell RNA sequencing and machine learning, revealing their antigen-experienced features and cytotoxic potential.
bioRxiv · Jan 2, 2026 · PreprintImmunology