Author

William Rostain

Centre National de la Recherche ScientifiqueORCID 0000-0002-9960-4669Unclaimed ORCID profile · follow to get notified of new preprints

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William Rostain2 papers

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

Cyril MalbrankeiD· 1 shared David BikardiD· 1 shared Florence DepardieuiD· 1 shared Rémi MonassoniD· 1 shared Simona CoccoiD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperBioinformatics

Cyril MalbrankeORCID

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1 paper

Recent·Most cited

Computational design of novel Cas9 PAM-interacting domains using evolution-based modelling and structural quality assessment

Cyril Malbranke, William Rostain, Florence Depardieu, Simona Cocco, Rémi Monasson, David Bikard

The paper designs novel Cas9 PAM-interacting domains using a combination of evolutionary modeling, physics-based scoring, and machine learning, identifying functional variants with up to 20% sequence divergence from the wild-type.

PLoS Computational Biology · Nov 17, 2023Peer-reviewedBioinformatics