A constraints-based theory of the primary cause of senescence: imbalance of epigenetic and non-epigenetic information in histone crosstalk
The paper proposes a theory that senescence arises from an imbalance between epigenetic and non-epigenetic information in histone crosstalk, leading to transcriptional overregulation and dysfunctionality.
bioRxiv · Mar 25, 2022 · PreprintDevelopmental Biology