Brian C. Zhang

A scalable approach for genome-wide inference of ancestral recombination graphs

The paper introduces Threads, a method for efficiently inferring ancestral recombination graphs from large genomic datasets, improving imputation accuracy and trait association detection.

Biobank-scale inference of ancestral recombination graphs enables genealogy-based mixed model association of complex traits

The paper introduces a method to infer genealogies from biobank-scale data and uses them in mixed models to detect associations with complex traits, finding more rare variants than traditional imputation methods.