BioengineeringMetabolic EngineeringPeer-reviewed
Improving HEK293-based AAV-production using GSMMs, and a multi-omics approach
Leopold Zehetner, Diana Széliová, B. Kraus…·Jürgen Zanghellini
This study uses multi-omics analysis and GSMMs to identify metabolic bottlenecks in HEK293 cell AAV production, revealing HIF1alpha's role in pseudohypoxia and its impact on viral yield.
8 citations